Space-Based Capstone: Public-Private-Academic Partnership in the Making

The Electronic Systems Engineering Technology (ESET) Program at Texas A&M University provides a recognized undergraduate program with an emphasis in electronics, communication, embedded systems, testing, instrumentation and control systems. The program combines engineering and industrial knowledge and methods to develop, design, and implement new innovative products through a two-semester long Senior Capstone Project. Capstone is designed to prepare future engineers by bridging the gap between the classroom and industry. Students are required to form teams of two to six members which allows them to develop the skills necessary to succeed in a diverse industry setting. Each team is required to use their knowledge and skills to design, develop, document, and deliver a real-world project equivalent to the assignments they will soon receive as professional engineers. Following NASA’s approval for funding the development of a research facility named Hermes, a Capstone team, named Microgravity Automated Research Systems (MARS), was sponsored by T STAR, a local space commercialization company, to develop the electronics portion of the facility. Hermes will reside on the International Space Station for five years in the hopes of streamlining the development of experiments that require extended periods of time in microgravity environments. The Hermes facility will host and manage up to four experiments at a time while allowing for the downlink of experiment data to an Earth station, and the uplink of commands to change experiment parameters. Experiments will adhere to a power budget and communication standard established by MARS so that experiments can be swapped out during the facility’s lifetime. MARS will work with the Mobile Integrated Solutions Laboratory (MISL), an undergraduate applied research lab, in order to prepare them to maintain support for Hermes in the future.Cockrell School of Engineerin

Failure of a pan-Mayan Party? Explaining Mayan Political Participation in Guatemala

Over the past 20 years, indigenous groups across Latin America have gained significant ground in their respective countries’ national politics. Factors relating to institutional reforms and effective populist appeals have created several successful national indigenous parties in Bolivia and Ecuador in particular. Guatemala is a case that many scholars are puzzled by because it shares many similarities of the Ecuadorian and Bolivian political and ethnic landscapes, but has not developed a national indigenous party. The research pertaining to the rise of Latin American indigenous parties can be understood in two prominent groups. Institutionalists point to changes in electoral rules as a determining factor. In addition, institutionalists concentrate on nationwide politics, not local politics. The second group, ethnopopulists, explain that the rise of indigenous parties is due to these parties making indigenous and populist claims without alienating the non-indigenous population. However, neither of these approaches adequately addresses this so-called “failure” of the Maya in Guatemala to form a pan-Mayan party. This thesis challenges both of these narratives by focusing on Mayan participation at the local level. I argue that traditional institutions at the city/village level influence the Mayan population to participate locally. Additionally, divisions within the Mayan community prevent a level of unity necessary to build a political party to run at the national level. Although I question the limitations of these two approaches, I find it unlikely a pan-Mayan will form in the foreseeable future due to the Mayas preference to participate solely at the local leve

Enhanced Diffusivity in Metal-Organic Frameworks for Use as a Drug Delivery System

The pharmaceutical industry is undergoing a transformative shift toward personalized medicine and new methods for controlled delivery of those drugs are necessary. MOFs are an exciting potential sorbent due to their extremely high surface areas (1,000 m^2/g and 10,000 m^2/g) and ultrafine molecular sieving ability. In this project, we designed, constructed, and validated a system and mathematical model for assessing the drug release profiles from porous media. The work culminates with a systematic perspective identifying the need for stable, size-tunable frameworks that could serve as an excellent and effective drug delivery system

Identifying metabolites from protein identifiers with P2M

The identification of metabolites from complex biological samples often involves matching experimental mass spectrometry data to signatures of compounds derived from massive chemical databases. However, misidentifications may result due to the complexity of potential chemical space that leads to databases containing compounds with nearly identical structures. Prior knowledge of compounds that may be enzymatically consumed or produced by an organism can help reduce misidentifications by restricting initial database searching to compounds that are likely to be present in a biological system. While databases such as UniProt allow for the identification of small molecules that may be consumed or generated by enzymes encoded in an organism's genome, currently no tool exists for identifying SMILES strings of metabolites associated with protein identifiers and expanding R-containing substructures to fully defined, biologically relevant chemical structures. Here we present Proteome2Metabolome (P2M), a tool that performs these tasks using external database querying behind a simple command line interface. Beyond mass spectrometry based applications, P2M can be generally used to identify biologically relevant chemical structures likely to be observed in a biological system

SSC Engineering Analysis

A package for the automation of the Engineering Analysis (EA) process at the Stennis Space Center has been customized. It provides the ability to assign and track analysis tasks electronically, and electronically route a task for approval. It now provides a mechanism to keep these analyses under configuration management. It also allows the analysis to be stored and linked to the engineering data that is needed to perform the analysis (drawings, etc.). PTC s (Parametric Technology Corp o ration) Windchill product was customized to allow the EA to be created, routed, and maintained under configuration management. Using Infoengine Tasks, JSP (JavaServer Pages), Javascript, a user interface was created within the Windchill product that allows users to create EAs. Not only does this interface allow users to create and track EAs, but it plugs directly into the out-ofthe- box ability to associate these analyses with other relevant engineering data such as drawings. Also, using the Windchill workflow tool, the Design and Data Management System (DDMS) team created an electronic routing process based on the manual/informal approval process. The team also added the ability for users to notify and track notifications to individuals about the EA. Prior to the Engineering Analysis creation, there was no electronic way of creating and tracking these analyses. There was also a feature that was added that would allow users to track/log e-mail notifications of the EA

Misreporting in a randomized clinical trial for smoking cessation in adolescents

Introduction: Misreporting smoking behavior is common among younger smokers participating in clinical trials for smoking cessation. This study focused on the prevalence of and factors associated with adolescent misreporting of smoking behaviors within the context of a randomized clinical trial for smoking cessation. Methods: Adolescent smokers (N = 129) participated in a randomized clinical trial that compared two brief interventions for smoking cessation. Following the final (6-month) follow-up, a confidential, self-administered exit questionnaire examined the extent to which participants admitted to having misreported smoking quantity, frequency and/or consequences during the study. Factors associated with under- and over-reporting were compared to accurate-reporting. Results: One in 4 adolescent smokers (25.6%) admitted to under-reporting during the study and 14.7% admitted to over-reporting; 10.9% of the adolescents admitted to both under- and over-reporting. Rates of admitted misreporting did not differ between treatment conditions or recruitment site. Compared to accurate-reporting, under- and over-reporting were significantly associated with home smoking environment and the belief among adolescents that the baseline interviewer wanted them to report smoking more or less than they actually smoked. Compared to accurate reporters, over-reporters were more likely to be non-White and to report being concerned with the confidentiality of their responses. Conclusions: A post-study confidential debriefing questionnaire can be a useful tool for estimating rates of misreporting and examining whether potential differences in misreporting might bias the interpretation of treatment effects. Future studies are needed to thoroughly examine potentially addressable reasons that adolescents misreport their smoking behavior and to develop methods for reducing misreporting